Keynote Speakers

 

Prof. Sung Wing Kin, Ken                                                                                                    

National University of Singapore, Singapore

 

Prof. Dr. Wing-Kin Sung received both the B.Sc. and the Ph.D. degree in the Department of Computer Science from the University of Hong Kong in 1993, 1998, respectively. He is a professor in the Department of Computer Science, School of Computing, NUS. Also, he is a senior group leader in Genome Institute of Singapore. He has over 20 years experience in Algorithm and Bioinformatics research. He also teaches courses on bioinformatics for both undergraduate and postgraduate. He was conferred the 2003 FIT paper award (Japan), the 2006 National Science Award (Singapore), and the 2008 Young Researcher Award (NUS) for his research contribution in algorithm and bioinformatics.

 

Speech Title: "Finding Transpositions in Repeat Regions Using High-Throughput Sequencing Data"

 

Abstract: Structural variations (SVs) are important since they can cause diseases. They can be discovered using second generation sequencing. The performance of existing software is good enough to call them if they are in non-repeat regions. However, when the SVs are in repeat regions. The performance is bad. For example, for insertion events, existing software can call less than 10% of the enchmark insertion events. In this talk, we will check if we can improve the performance of SV calling. In particular, we focused on transpositions. When compare with existing SV callers (without database), we shows at least 3 folds improvements in sensitivity for calling transpositions in repeat regions.

 

Prof. Tatsuya Akutsu                                                                                                             

Kyoto University, Japan

 

Tatsuya Akutsu received the B.E. and M.E. degrees in aeronautics and the D.E. degree in information engineering from the University of Tokyo, Japan, in 1984, 1986, and 1989, respectively. From 1989 to 1994, he was with Mechanical Engineering Laboratory, Japan. From 1994 to 1996, he was an Associate Professor in the Department of Computer Science at Gunma University, Japan. From 1996 to 2001, he was an Associate Professor in Human Genome Center, Institute of Medical Science, University of Tokyo, Japan. Since 2001, he has been a Professor in Bioinformatics Center, Institute for Chemical Research, Kyoto University. His research interests include bioinformatics, discrete algorithms, and complex networks. He is an associate editor of BMC Bioinformatics and IEEE/ACM Transactions on Computational Biology and Bioinformatics.

 

Speech Title: "Integration and Analysis of Heterogeneous Biological Data via Convolutional Neural Networks and Matrix Factorization"

 

Abstract: Integrating heterogeneous data is becoming an important topic in bioinformatics. Here we present three of our approaches to heterogeneous data analysis. The first one is based on convolutional neural networks. In this method, protein interaction network data were integrated with transcriptome data by embedding the network structure into image data via spectral clustering. The developed spectral-convolutional neural network based method was applied to classification of lung cancer. The second one is also based on convolutional neural networks. In this case, gene correlation and distance data were integrated with transcriptome data by embedding the distance data into image data via multidimensional scaling, and the resulting method was applied to classification of cancer subtypes. The third one is an application of an existing matrix tri-factorization technique. In this work, relations between proteases, protein targets, genes, pathways and domains were integrated via matrix tri-factorization for prediction of protease-target relations.

 

Distinguished Prof. Cuie Wen                                                                                                  

RMIT University, Australia

 

Cuie joined RMIT University as Professor of Biomaterials Engineering in 2014 and she has been appointed Distinguished Professor in 2015. She was Professor of Surface Engineering at Swinburne University of Technology from 2010 to 2014. She worked at Deakin University from 2003 to 2010 as Research Fellow, Senior Researcher and Associate Professor. Cuie has won a number of industrial and national competitive grants. Cuie has published more than 360 peer reviewed articles with an H index 44 and citations over 7704 (Google Scholar). Cuie has supervised 10 postdoctoral research projects, 25 post graduate students to completion. She is an editorial board member for the journals of Acta Biomaterialia, and Bioactive Materials. Her research interests include new biocompatible titanium, magnesium, iron, zinc and their alloys and scaffolds for biomedical applications, surface modification, nanostructured metals, alloys and composites, metal foams and nanolaminates.
.

 

Speech Title: "Titanium-based Nickel-Free Shape Memory Alloy Scaffolds for Biomedical Applications"

 

Abstract: Titanium and some of its alloys are widely used as load-bearing dental and orthopaedic implant materials due to their excellent biocompatibility, relatively good mechanical properties and high corrosion resistance in the physiological environment. In particular, titanium-based nickel-free shape memory alloys (SMAs) are fascinating biomaterials for implant applications as their unique shape memory property and superelasticity provide the possibility of preparing self-expanding, self-compressing and other functional implants. Our research in developing new titanium-based biomaterials include the assessment of the cytotoxicity of metal alloying elements and identify the ideal biocompatible alloying elements; as well as 3D printing the new titanium alloys into a porous structure with bone-mimicking architecture. The porous structure not only allows new bone tissue ingrowth and vascularisation, but also provides low elastic modulus matching that of natural bone. Furthermore, the new porous alloys offer advantages of shape memory and superelastic effects, which benefit the bone healing process.

 

Prof. Kuo-Sheng Cheng                                                                                                         

National Cheng Kung University, Taiwan

 

Prof. Kuo-Sheng Cheng received his B.Sc, M.Sc, and Ph.D degrees from Department of Electrical Engineering, National Cheng Kung University, Tainan, TAIWAN. He also received his M.Sc degree from Department of Biomedical Engineering, Rensselaer Polytechnic Institute, USA. Currently, he is a professor with the Department of Biomedical Engineering, National Cheng Kung University. He also is the Director of Department of Maintenance and Engineering, National Cheng Kung University Hospital and the Director of Engineering and Technology Promotion Center, which is financial supported by Ministry of Science and Technology, TAIWAN. He was the past President of the Biomedical Engineering Society of TAIWAN. His research interests includes medical image processing, electrical impedance imaging and biomedical instrumentation.

 

Speech Title: "Medical Applications and Future Trends of Bioimpedance Technology"

 

Abstract: Bioimpedance technology is one of the simple and easy methods to characterize property of the biological materials and physiological functions. It is a technique that applies the electrical voltage or current and measures the resulting current or voltage using single or multiple frequencies through electrodes. Based on these electrical application and measurement, the bioimpedance may then be obtained for tissues characterization such as body composition estimation, cancel differentiation, etc, as well as physiological functions analysis such as impedance cardiography, bioimpedance myography, etc. In addition, it may be further applied as electrical impedance tomography for producing the imaging to reveal the electrical properties of different tissues within body. Basing on these physiological functions or tissue properties, the diagnosis and prognosis may be directly or indirectly made. From the aspects of medical applications, the applications of electrical impedance tomography for pulmonary function analysis, bioimpedance myography for skeletal muscle characterization, bioimpedance spectroscopy for cancer cell differentiation may be possible future directions.

 

 

Assoc. Prof. Hiroyuki KUDO                                                                                                   

Meiji University, Japan

 

Prof. Dr. Hiroyuki Kudo received both the M.E. and Ph.D. degrees in the Department of Electronics and Communications from Waseda University in 1999 and 2004, respectively. He was a research officer of MEMS laboratory, Tokyo Metropolitan Industrial Technology Research Institute from 2003 to 2007. He worked at Tokyo Medical and Dental University as an assistant professor from 2005, a junior associate professor from 2007 to 2011 and an associate professor from 2011 to 2013. Currently, he has been an associate professor of Department of Electronics at Meiji University. Currently, his research interests include biomicrosystems based on enzymatic biosensors and immunosensors and for life science applications.

 

Speech Title: "Non-invasive Bioinstrumentation for Next Generation Medicine and Healthcare"

 

Abstract: Recent advances in information technologies have been expected to bring a paradigm shift in medicine and personal healthcare fields. Some biometric- or physiological information (e.g. body weight, body temperature, body fat, etc.) has already been utilized in personal health services. In contrast, it is still difficult to use biochemical information such as blood component in those services because conventional techniques for determination of biochemical information usually requires blood sampling. Therefore, non-invasive method for blood content assessment is strongly requested for next generation medicine and healthcare. Non-invasive biomonitoring usually measures contents of body fluids (saliva, sweat, tear, urine and so on), that reflects blood contents. It is necessary to simplify whole procedure from ‘sampling’ to ‘measurement’ to be anyone can easily do within a short time and reasonable cos for this purposes We have been developed new biosensors and biomicorsystems capable of personal use. In this talk, our recent status of sensing system development and possible applications will be presented.

 

Invited Speaker

 

Assoc. Prof. Yuncang Li                                                                                                     

RMIT University, Australia

 

Associate Professor Yuncang Li obtained his PhD in Materials Science Engineering from Deakin University in 2004 and then took up a research position in Biomaterials Engineering at Deakin University until the end of 2014. He joined RMIT University in 2015. He was awarded an Australian Research Council (ARC) Future Fellowship in 2016. Dr Li has won a number of national competitive grants including ARC and National Health and Medical Research Council (NHMRC) projects. His research focuses on developing metallic biomaterials for medical applications. He published over 150 journal papers and 7 book chapters and filed 5 patents. He has expertise in microstructure-mechanical property relationships, corrosion, and biocompatibility, surface modification, nanostructured metals and alloys, and metal foams.

 

Speech Title: "Development of Biocompatible Magnesium-Zirconium-Strontium Alloys for Biodegradable Implant Materials"

 

Abstract: Magnesium (Mg) based alloys have been extensively considered for their use as biodegradable implant materials. However, controlling their corrosion rate in the physiological environment of the human body is still a significant challenge. One of the most effective approaches to address this challenge is to strategically design new Mg alloys with enhanced corrosion resistance, biocompatibility, and mechanical properties. Our research has developed new series of Mg-zirconium (Zr)-strontium (Sr)-rare earth element (REE) alloys for biodegradable implant applications. Research results indicate that Sr and Zr additions can refine the grain size and enhance the corrosion and biological behaviors of the Mg alloys. Furthermore, the addition of holmium (Ho) and dysprosium (Dy) to Mg-Zr-Sr alloys resulted in enhanced mechanical strength and decreased degradation rate. In addition, less than 5 wt.% Ho and Dy additions to Mg-Zr-Sr alloys led to enhancement of cell adhesion and proliferation of osteoblast cells on the Mg-Zr-Sr-Ho/Dy alloys.

 

 

 

 

 

Previous Speakers

 

Prof. Wen-Lian Hsu
Academia Sinica, Taiwan
Prof. Kenta Nakai
The University of Tokyo, Japan
Prof. Keimei Oh
Akita Prefectual University, Japan
Prof. Manoj R. Tarambale
Marathwada Mitra Mandal’s College of Engineering, India
Assoc. Prof. Siew Woh Choo
Xi'an Jiatong-Liverpool University, China
Assoc. Prof. Riichi Kajiwara
Meiji University, Japan